| 1 | Amgen Inc | AMGN:US | Health Care | $38.1B | 28.9 | $251.9B |
| 2 | Gilead Sciences Inc | GILD:US | Health Care | $31.0B | - | $211.7B |
| 3 | Intuitive Surgical Inc | ISRG:US | Health Care | $11.6B | 52.2 | $152.6B |
| 4 | Vertex Pharmaceuticals Inc | VRTX:US | Health Care | $12.6B | 32.5 | $141.7B |
| 5 | Sanofi ADR | SNY:US | Health Care | $51.0B | 22.1 | $106.2B |
| 6 | Regeneron Pharmaceuticals Inc | REGN:US | Health Care | $16.9B | 20.5 | $96.0B |
| 7 | Moderna Inc | MRNA:US | Health Care | $2.2B | - | $88.2B |
| 8 | Natera Inc | NTRA:US | Health Care | $2.7B | - | $59.7B |
| 9 | argenx NV ADR | ARGX:US | Health Care | $5.9B | 30.9 | $56.1B |
| 10 | IDEXX Laboratories Inc | IDXX:US | Health Care | $4.6B | 38.7 | $52.9B |
| 11 | Agilent Technologies Inc | A:US | Health Care | $7.4B | 29.7 | $43.3B |
| 12 | Medline Inc. Class A Common Stock | MDLN:US | Health Care | $29.9B | 80.3 | $43.2B |
| 13 | BeiGene, Ltd. | ONC:US | Health Care | $6.1B | 64.6 | $41.1B |
| 14 | Revolution Medicines Inc | RVMD:US | Health Care | $742,000 | - | $41.0B |
| 15 | Royalty Pharma Plc | RPRX:US | Health Care | $2.5B | 35.7 | $38.8B |
| 16 | Biogen Inc | BIIB:US | Health Care | $10.3B | 107.8 | $36.8B |
| 17 | GE HealthCare Technologies Inc. | GEHC:US | Health Care | $21.6B | 16.8 | $36.0B |
| 18 | Illumina Inc | ILMN:US | Health Care | $4.5B | 39.0 | $34.3B |
| 19 | Genmab AS | GMAB:US | Health Care | $4.1B | 43.2 | $33.8B |
| 20 | DexCom Inc | DXCM:US | Health Care | $5.1B | 33.4 | $31.6B |
| 21 | Roivant Sciences Ltd | ROIV:US | Health Care | $8M | - | $26.7B |
| 22 | United Therapeutics Corporation | UTHR:US | Health Care | $3.2B | 21.4 | $25.6B |
| 23 | Incyte Corporation | INCY:US | Health Care | $6.0B | 61.4 | $24.5B |
| 24 | Insmed Inc | INSM:US | Health Care | $1.5B | - | $24.0B |
| 25 | Guardant Health Inc | GH:US | Health Care | $1.2B | - | $22.9B |
| 26 | Alnylam Pharmaceuticals Inc | ALNY:US | Health Care | $5.0B | 8.3 | $22.1B |
| 27 | BioNTech SE | BNTX:US | Health Care | $2.6B | - | $22.0B |
| 28 | Viatris Inc | VTRS:US | Health Care | $14.7B | - | $21.9B |
| 29 | Medpace Holdings Inc | MEDP:US | Health Care | $2.8B | 36.2 | $18.2B |
| 30 | Exelixis Inc | EXEL:US | Health Care | $2.5B | 21.0 | $17.1B |
| 31 | Ascendis Pharma AS | ASND:US | Health Care | $1.0B | 19.3 | $16.5B |
| 32 | ICON PLC | ICLR:US | Health Care | $8.2B | 84.5 | $15.8B |
| 33 | Neurocrine Biosciences Inc | NBIX:US | Health Care | $3.4B | 21.4 | $14.8B |
| 34 | Halozyme Therapeutics Inc | HALO:US | Health Care | $1.7B | 37.7 | $14.6B |
| 35 | BridgeBio Pharma Inc | BBIO:US | Health Care | $946M | - | $14.6B |
| 36 | Tempus AI, Inc. Class A Common Stock | TEM:US | Health Care | $1.4B | - | $14.3B |
| 37 | Jazz Pharmaceuticals PLC | JAZZ:US | Health Care | $4.6B | 63.4 | $13.9B |
| 38 | BrightSpring Health Services, Inc. Common Stock | BTSG:US | Health Care | $15.3B | 47.0 | $13.2B |
| 39 | Summit Therapeutics PLC | SMMT:US | Health Care | - | - | $12.8B |
| 40 | The Cooper Companies, Inc | COO:US | Health Care | $4.2B | 21.1 | $11.7B |
| 41 | Bio-Techne Corp | TECH:US | Health Care | $1.2B | 62.6 | $11.4B |
| 42 | Biomarin Pharmaceutical Inc | BMRN:US | Health Care | $3.4B | 158.1 | $11.3B |
| 43 | Repligen Corporation | RGEN:US | Health Care | $806M | - | $11.1B |
| 44 | Kymera Therapeutics Inc | KYMR:US | Health Care | $102M | - | $10.8B |
| 45 | Insulet Corporation | PODD:US | Health Care | $3.1B | 28.8 | $10.7B |
| 46 | Align Technology Inc | ALGN:US | Health Care | $4.2B | 21.8 | $10.6B |
| 47 | The Ensign Group Inc | ENSG:US | Health Care | $5.7B | 27.0 | $10.4B |
| 48 | Bausch + Lomb Corp | BLCO:TO | Health Care | $5.4B | - | $10.0B |
| 49 | Madrigal Pharmaceuticals Inc | MDGL:US | Health Care | $1.3B | - | $9.9B |
| 50 | Krystal Biotech Inc | KRYS:US | Health Care | $440M | 41.6 | $9.8B |
| 51 | Vaxcyte Inc | PCVX:US | Health Care | - | - | $9.8B |
| 52 | Caris Life Sciences, Inc. Common Stock | CAI:US | Health Care | $990M | 20.3 | $9.7B |
| 53 | Henry Schein Inc | HSIC:US | Health Care | $13.6B | 24.7 | $9.7B |
| 54 | Protagonist Therapeutics Inc | PTGX:US | Health Care | $282M | 140.6 | $9.4B |
| 55 | TG Therapeutics Inc | TGTX:US | Health Care | $800M | 22.2 | $9.4B |
| 56 | 10X Genomics Inc | TXG:US | Health Care | $617M | - | $9.1B |
| 57 | Spyre Therapeutics Inc. | SYRE:US | Health Care | - | - | $8.9B |
| 58 | Immunitybio Inc | IBRX:US | Health Care | $166M | - | $8.8B |
| 59 | Cytokinetics Inc | CYTK:US | Health Care | $68M | - | $8.8B |
| 60 | Corcept Therapeutics Incorporated | CORT:US | Health Care | $831M | 178.8 | $8.7B |
| 61 | Bruker Corporation | BRKR:US | Health Care | $3.5B | - | $8.7B |
| 62 | Twist Bioscience Corp | TWST:US | Health Care | $432M | - | $8.6B |
| 63 | HealthEquity Inc | HQY:US | Health Care | $1.4B | 37.0 | $8.5B |
| 64 | Arrowhead Pharmaceuticals Inc | ARWR:US | Health Care | $669M | - | $8.4B |
| 65 | Praxis Precision Medicines Inc | PRAX:US | Health Care | $7M | - | $8.0B |
| 66 | Axsome Therapeutics Inc | AXSM:US | Health Care | $777M | - | $7.6B |
| 67 | Alkermes Plc | ALKS:US | Health Care | $1.7B | 118.1 | $7.5B |
| 68 | Abivax SA American Depositary Shares | ABVX:US | Health Care | $5M | - | $7.4B |
| 69 | Ionis Pharmaceuticals Inc | IONS:US | Health Care | $874M | - | $7.2B |
| 70 | Kiniksa Pharmaceuticals Ltd | KNSA:US | Health Care | $946M | 68.8 | $7.1B |
| 71 | Amneal Pharmaceuticals, Inc. Class A Common Stock | AMRX:US | Health Care | $3.1B | 41.7 | $7.1B |
| 72 | Lantheus Holdings Inc | LNTH:US | Health Care | $1.6B | 24.3 | $6.6B |
| 73 | Ligand Pharmaceuticals Incorporated | LGND:US | Health Care | $307M | 34.0 | $6.4B |
| 74 | Rhythm Pharmaceuticals Inc | RYTM:US | Health Care | $240M | - | $6.4B |
| 75 | Oruka Therapeutics, Inc. | ORKA:US | Health Care | - | - | $6.3B |
| 76 | Belite Bio Inc ADR | BLTE:US | Health Care | - | - | $6.2B |
| 77 | Kodiak Sciences Inc | KOD:US | Health Care | - | - | $6.1B |
| 78 | Immunovant Inc | IMVT:US | Health Care | - | - | $6.0B |
| 79 | GRAIL, LLC | GRAL:US | Health Care | $165M | - | $6.0B |
| 80 | RadNet Inc | RDNT:US | Health Care | $2.3B | - | $5.8B |
| 81 | Mirum Pharmaceuticals Inc | MIRM:US | Health Care | $618M | - | $5.6B |
| 82 | Grifols SA ADR | GRFS:US | Health Care | $7.4B | 10.5 | $5.5B |
| 83 | CG Oncology, Inc. Common stock | CGON:US | Health Care | $6M | - | $5.5B |
| 84 | Cogent Biosciences Inc | COGT:US | Health Care | - | - | $5.4B |
| 85 | Waystar Holding Corp. Common Stock | WAY:US | Health Care | $1.2B | 40.0 | $5.4B |
| 86 | BillionToOne, Inc. Class A Common Stock | BLLN:US | Health Care | $397M | 179.9 | $5.3B |
| 87 | Scholar Rock Holding Corp | SRRK:US | Health Care | - | - | $5.2B |
| 88 | Sotera Health Co | SHC:US | Health Care | $1.2B | 31.8 | $5.2B |
| 89 | Merit Medical Systems Inc | MMSI:US | Health Care | $1.6B | 32.3 | $5.2B |
| 90 | MiniMed Group, Inc. Common Stock | MMED:US | Health Care | $3.2B | - | $5.1B |
| 91 | Heartflow, Inc. Common Stock | HTFL:US | Health Care | $212M | - | $5.1B |
| 92 | Lifestance Health Group Inc | LFST:US | Health Care | $1.6B | 103.1 | $5.1B |
| 93 | PTC Therapeutics Inc | PTCT:US | Health Care | $1.2B | - | $5.1B |
| 94 | Erasca Inc | ERAS:US | Health Care | - | - | $5.0B |
| 95 | Crispr Therapeutics AG | CRSP:US | Health Care | $13M | - | $5.0B |
| 96 | Definium Therapeutics, Inc. | DFTX:US | Health Care | - | - | $4.9B |
| 97 | Travere Therapeutics Inc | TVTX:US | Health Care | $591M | - | $4.7B |
| 98 | Option Care Health Inc | OPCH:US | Health Care | $5.7B | 24.0 | $4.7B |
| 99 | Dianthus Therapeutics Inc. | DNTH:US | Health Care | $2M | - | $4.6B |
| 100 | CareDx Inc | CDNA:US | Health Care | $497M | 36.9 | $4.6B |
| 101 | LivaNova PLC | LIVN:US | Health Care | $1.5B | 23.4 | $4.3B |
| 102 | Indivior PLC Ordinary Shares | INDV:US | Health Care | $1.4B | 10.2 | $4.3B |
| 103 | Adaptive Biotechnologies Corp | ADPT:US | Health Care | $308M | - | $4.3B |
| 104 | Edgewise Therapeutics Inc | EWTX:US | Health Care | - | - | $4.2B |
| 105 | Bausch Health Companies Inc | BHC:TO | Health Care | $11.1B | - | $4.2B |
| 106 | CorVel Corp | CRVL:US | Health Care | $984M | 37.2 | $4.2B |
| 107 | Legend Biotech Corp | LEGN:US | Health Care | $1.3B | - | $4.1B |
| 108 | ICU Medical Inc | ICUI:US | Health Care | $2.2B | 137.6 | $4.1B |
| 109 | iRhythm Technologies Inc | IRTC:US | Health Care | $825M | - | $4.1B |
| 110 | Relay Therapeutics Inc | RLAY:US | Health Care | $10M | - | $4.0B |
| 111 | Abcellera Biologics Inc | ABCL:US | Health Care | $66M | - | $4.0B |
| 112 | Veracyte Inc | VCYT:US | Health Care | $562M | 35.0 | $3.9B |
| 113 | Arcutis Biotherapeutics Inc | ARQT:US | Health Care | $464M | 148.9 | $3.9B |
| 114 | Iovance Biotherapeutics Inc | IOVA:US | Health Care | $325M | - | $3.8B |
| 115 | Tango Therapeutics Inc | TNGX:US | Health Care | $54M | - | $3.8B |
| 116 | Liquidia Technologies Inc | LQDA:US | Health Care | $451M | 32.4 | $3.7B |
| 117 | Pulse Biosciences Inc | PLSE:US | Health Care | $1M | - | $3.7B |
| 118 | Xenon Pharmaceuticals Inc | XENE:US | Health Care | - | - | $3.6B |
| 119 | Amylyx Pharmaceuticals Inc | AMLX:US | Health Care | $-665,000 | - | $3.6B |
| 120 | ACADIA Pharmaceuticals Inc | ACAD:US | Health Care | $1.1B | 9.2 | $3.5B |
| 121 | Parabilis Medicines, Inc. Common Stock | PBLS:US | Health Care | $148,000 | - | $3.5B |
| 122 | Disc Medicine Inc. | IRON:US | Health Care | - | - | $3.5B |
| 123 | Viking Therapeutics Inc | VKTX:US | Health Care | - | - | $3.5B |
| 124 | Tarsus Pharmaceuticals Inc | TARS:US | Health Care | $606M | - | $3.4B |
| 125 | Celcuity LLC | CELC:US | Health Care | - | - | $3.4B |
| 126 | Regencell Bioscience Holdings Ltd | RGC:US | Health Care | - | - | $3.3B |
| 127 | Enliven Therapeutics Inc. | ELVN:US | Health Care | - | - | $3.3B |
| 128 | Dyne Therapeutics Inc | DYN:US | Health Care | - | - | $3.2B |
| 129 | Telix Pharmaceuticals Limited | TLX:US | Health Care | $891M | 90.5 | $3.1B |
| 130 | Ideaya Biosciences Inc | IDYA:US | Health Care | $234M | - | $3.1B |
| 131 | AtriCure Inc | ATRC:US | Health Care | $570M | 285.1 | $3.0B |
| 132 | Denali Therapeutics Inc | DNLI:US | Health Care | $4M | - | $3.0B |
| 133 | Surgery Partners Inc | SGRY:US | Health Care | $3.4B | - | $3.0B |
| 134 | Axogen Inc | AXGN:US | Health Care | $267M | - | $2.9B |
| 135 | Nurix Therapeutics Inc | NRIX:US | Health Care | $702M | 11.0 | $2.9B |
| 136 | Maravai Lifesciences Holdings Inc | MRVI:US | Health Care | $209M | - | $2.9B |
| 137 | Aveanna Healthcare Holdings Inc | AVAH:US | Health Care | $2.6B | 10.4 | $2.9B |
| 138 | Beam Therapeutics Inc | BEAM:US | Health Care | $156M | - | $2.8B |
| 139 | Viridian Therapeutics Inc | VRDN:US | Health Care | $71M | - | $2.8B |
| 140 | Acadia Healthcare Company Inc | ACHC:US | Health Care | $3.4B | - | $2.8B |
| 141 | Privia Health Group Inc | PRVA:US | Health Care | $2.4B | 102.3 | $2.7B |
| 142 | Zai Lab Ltd | ZLAB:US | Health Care | $450M | - | $2.7B |
| 143 | ATAI Life Sciences BV | ATAI:US | Health Care | $4M | - | $2.7B |
| 144 | MBX Biosciences, Inc. Common Stock | MBX:US | Health Care | - | - | $2.6B |
| 145 | Neogen Corporation | NEOG:US | Health Care | $884M | - | $2.6B |
| 146 | Extendicare Inc | EXE:TO | Health Care | $2.0B | 20.1 | $2.5B |
| 147 | ADMA Biologics Inc | ADMA:US | Health Care | $512M | 15.8 | $2.5B |
| 148 | Supernus Pharmaceuticals Inc | SUPN:US | Health Care | $865M | - | $2.4B |
| 149 | Recursion Pharmaceuticals Inc | RXRX:US | Health Care | $55M | - | $2.4B |
| 150 | Pharvaris BV | PHVS:US | Health Care | - | - | $2.4B |
| 151 | Addus HomeCare Corporation | ADUS:US | Health Care | $1.5B | 22.0 | $2.3B |
| 152 | TransMedics Group Inc | TMDX:US | Health Care | $668M | 17.1 | $2.3B |
| 153 | Clover Health Investments Corp | CLOV:US | Health Care | $2.5B | - | $2.3B |
| 154 | NewAmsterdam Pharma Company N.V. Ordinary Shares | NAMS:US | Health Care | $7M | - | $2.3B |
| 155 | HUTCHMED DRC | HCM:US | Health Care | $549M | 131.5 | $2.3B |
| 156 | Celldex Therapeutics Inc | CLDX:US | Health Care | $158,000 | - | $2.3B |
| 157 | Harmony Biosciences Holdings | HRMY:US | Health Care | $960M | 12.5 | $2.3B |
| 158 | Progyny Inc | PGNY:US | Health Care | $1.3B | 31.7 | $2.2B |
| 159 | Aurinia Pharmaceuticals Inc | AUPH:US | Health Care | $322M | 7.3 | $2.2B |
| 160 | Xencor Inc | XNCR:US | Health Care | $105M | - | $2.2B |
| 161 | UFP Technologies Inc | UFPT:US | Health Care | $632M | 30.7 | $2.2B |
| 162 | Sienna Senior Living Inc | SIA:TO | Health Care | $1.1B | 37.1 | $2.2B |
| 163 | Vera Therapeutics Inc | VERA:US | Health Care | - | - | $2.2B |
| 164 | BioCryst Pharmaceuticals Inc | BCRX:US | Health Care | $941M | - | $2.2B |
| 165 | Immunome Inc | IMNM:US | Health Care | - | - | $2.1B |
| 166 | NeoGenomics Inc | NEO:US | Health Care | $788M | - | $2.1B |
| 167 | Lakefront Biotherapeutics NV | LKFT:US | Health Care | $991M | 3.1 | $2.1B |
| 168 | Alamar Biosciences, Inc. Common Stock | ALMR:US | Health Care | $100M | - | $2.1B |
| 169 | Palvella Therapeutics, Inc | PVLA:US | Health Care | - | - | $2.1B |
| 170 | Vericel Corp Ord | VCEL:US | Health Care | $306M | 85.7 | $2.1B |
| 171 | Zymeworks Inc. Common Stock | ZYME:US | Health Care | $37M | - | $2.1B |
| 172 | Septerna, Inc. Common Stock | SEPN:US | Health Care | $99M | - | $2.1B |
| 173 | Schrodinger Inc | SDGR:US | Health Care | $259M | - | $2.0B |
| 174 | Mesoblast Ltd | MESO:US | Health Care | $120M | - | $2.0B |
| 175 | Sarepta Therapeutics Inc | SRPT:US | Health Care | $2.0B | - | $2.0B |
| 176 | Trevi Therapeutics Inc | TRVI:US | Health Care | - | - | $1.9B |
| 177 | Hemab Therapeutics Holdings, Inc. Common Stock | COAG:US | Health Care | - | - | $1.9B |
| 178 | Fortrea Holdings Inc. | FTRE:US | Health Care | $2.7B | - | $1.9B |
| 179 | GeneDx Holdings Corp. | WGS:US | Health Care | $454M | - | $1.9B |
| 180 | Absci Corp | ABSI:US | Health Care | $2M | - | $1.9B |
| 181 | Dentsply Sirona Inc | XRAY:US | Health Care | $3.6B | - | $1.9B |
| 182 | First Tracks Biotherapeutics | TRAX:US | Health Care | - | - | $1.9B |
| 183 | BioLife Solutions Inc | BLFS:US | Health Care | $107M | 39.0 | $1.9B |
| 184 | Vir Biotechnology Inc | VIR:US | Health Care | $303M | - | $1.9B |
| 185 | LeMaitre Vascular Inc | LMAT:US | Health Care | $262M | 28.4 | $1.9B |
| 186 | Generate Biomedicines, Inc. Common Stock | GENB:US | Health Care | $26M | - | $1.9B |
| 187 | Xeris Pharmaceuticals Inc | XERS:US | Health Care | $335M | - | $1.9B |
| 188 | Replimune Group Inc | REPL:US | Health Care | - | - | $1.8B |
| 189 | Precigen Inc | PGEN:US | Health Care | $86M | - | $1.8B |
| 190 | Astrana Health Inc | ASTH:US | Health Care | $3.8B | 43.9 | $1.8B |
| 191 | Agios Pharm | AGIO:US | Health Care | $98M | - | $1.8B |
| 192 | Establishment Labs Holdings Inc | ESTA:US | Health Care | $264M | - | $1.8B |
| 193 | Zenas BioPharma, Inc. Common Stock | ZBIO:US | Health Care | $1M | - | $1.8B |
| 194 | Kestra Medical Technologies, Ltd. Common Stock | KMTS:US | Health Care | $107M | - | $1.8B |
| 195 | Intellia Therapeutics Inc | NTLA:US | Health Care | $60M | - | $1.7B |
| 196 | Cronos Group Inc | CRON:TO | Health Care | $179M | 18.1 | $1.7B |
| 197 | Sellas Life Sciences Group Inc | SLS:US | Health Care | - | - | $1.7B |
| 198 | Stoke Therapeutics Inc | STOK:US | Health Care | $28M | - | $1.7B |
| 199 | Azenta Inc | AZTA:US | Health Care | $614M | - | $1.7B |
| 200 | Maze Therapeutics, Inc. Common Stock | MAZE:US | Health Care | $20M | - | $1.7B |